One feature of large, high resolution displays is to present large datasets for analysis e. g. to a group of people. Especially for multiple users analyzing data, mouse and keyboard are only partially suited interacting with powerwall visualizations. To avoid disadvantages from mouse and keyboard interaction, in-air-gestures can be used to interact with the displayed data. Additionally gesture interaction provides a natural interface to powerwall visualizations. In this diploma thesis a concept to be able to interact with large, high resolution displays is developed based on two scenarios in which a powerwall is used for data analysis. To research the applicability of such an interaction concept a software prototype is implemented. This prototype supports one of the previously named scenarios. Also a user study is designed to evaluate the concept and identify more gestures for powerwall interaction. Additionally a framework is constructed that allows embedding the concept of powerwall interaction in a multi-modal environment with other interaction devices.