The success of the Cloud computing paradigm, together with the increase of Cloud providers and optimized Infrastructure-as-a-Service (IaaS) offerings have contributed to a raise in the number of research and industry communities that are strong supporters of migrating and running their applications in the Cloud. Focusing on eScience simulation-based applications, scientific workflows have been widely adopted in the last years, and the scientific workflow management systems have become strong candidates for being migrated to the Cloud. In this research work we aim at empirically evaluating multiple Cloud providers and their corresponding optimized and non-optimized IaaS offerings with respect to their offered performance, and its impact on the incurred monetary costs when migrating and executing a workflow-based simulation environment. The experiments show significant performance improvements and reduced monetary costs when executing the simulation environment in off-premise Clouds.