The current trend of connecting the physical world with the so-called cyber world resulted in paradigms such as the Internet of Things or the more general paradigm of Cyber-Physical Systems. The wide range of domains applicable results in a heterogeneous landscape of software and hardware solutions. To benefit of the paradigm, developers must be able to integrate different solutions from a range of different domains. However, these systems must therefore be able to change components, configurations and environments, hence, be adaptable at runtime. We present an approach that is based on the combination of Situation-Aware Adaptation concepts and Deployment Models. The general idea is to start processes that can change application structure and configuration when a certain situation in the context of applications occur. We validated the technical feasibility of our approach by a prototypical implementation based on a Smart Home scenario.